Welcome to "Parkinson's here and now" in 2020.

Welcome to "Parkinson's here and now" in 2020.

We only offer hope based on Science. Our sources are neurologists and other neuroscientists, we recommend always consulting with the neurologist and accepting levodopa, but only as long as there is nothing better and improving its effectiveness and correcting its adverse effects with the nutrients shown in the studies. Can there be anything more orthodox?

 

If you're tired of searching for information among tons of false news, commercials, columns of smoke, like on a merry-go-round, you may find reason for hope here. But real hope based on Science: in writings by neurologists, hundreds or thousands of scientific studies from the last 50 years, and testimonials and experiences from sick people and family caregivers.

What works is what interests us, whether it is levodopa-carbidopa with coenzyme Q10 or polyphenols from green tea, with 10-25 mg of vitamin B6 or milk thistle, or the amazing vitamin D3 supplement from the Suzuki study in 2013 or the wonderful riboflavin or vitamin B2 from the forgotten and doomed thousand-times study by Coimbra in 2003. Always with courage to search and prudence to try, consulting everything to the doctor.

 

This is a summary of almost 14 years of searching and about 26 years of looking at the world of Parkinson's since my father's diagnosis in 1994. I estimate that the result of more than 30,000 working hours.

1) Studies on DISEASE PREVENTION OR RISK REDUCTION:

 - with folic acid or B9, 49 % (Religa 2006);

 - with riboflavin or B2, 51 % (McCormick 1988);

 - coffee (caffeine, niacin, quercetin?), tobacco (nicotine?) and non-steroidal anti-inflammatory drugs - not aspirin - by 87 % (Powers 2008);

 - with vitamin D in certain cases, 67 % (Knekt 2010);

 - with vitamin C, 40 % (Hellebrand 1996);

 - with vitamin E, between 32 and 39 % (Zhang 2002, Golbe 1988)

 - with flanonoids, 40 % (Gao 2012)

 - with beta-carotene, 32 % (Hellenbrand 1996)

 - with green tea, in regions where it is  

   usual: 50 % less Parkinson's (Pan 2003)

 - with coffee: usual consumption of 2-3 cups per day, 20-70 % (Ascherio 2001, Sobel 2000, Ross, 2000, 2001). Among those who never drink coffee, the disease occurs 5 times more often (Ross 2000, Hu 2007)

 - with tobacco, between 40 and 55%, and more (Grandinetti 1994, Hernan 2001, 2002, Gallo 2019).

2) There are several promising studies on the possibility of DELAYING, SLOWING PROGRESSION AND EVEN STOPING Parkinson's:

 - coffee, delays symptoms by 8 years, from 64 to 72 (Benedetti 2000);

 - green tea, delays symptoms 7.7 years (Kandinov 2009);

 - vitamin C and E, 3 grams and 3200 IU daily, for one year: delay of need for medication by 2.5 years (Fahn 1992).

 - Vitamin C stimulates dopamine production and enhances the effect of levodopa, making lower doses necessary (Zhao 2019);

- multivitamin (A, C and E): delay of symptoms by 3 years, identical twins, epigenetic? (Maher 2002).

 - physical exercise, slows it down (Oguh 2014) and delays it (Tsai 2002);

 - vitamin D, 1200 IU for one year, no worsening (Suzuki 2013).

 - glutathione (Sechi 1996).

 - coenzyme Q10 (Shults 2002)

 - creatine (Beal 2003).

 - antioxidants (Grimes 1988).

 - omega 3 (Youdim 2000, Saugstad 2006, 2008).

 - alpha lipoic acid (Araujo 2011).

 - vitamin E (Bischot 1993).

 - green tea, EGCG extract (Mandel 2002, Levites 2003).

3) IMPROVE SYMPTOMS, MOTORS AND NON-MOTORS, that is, the evolution of the disease:

 - vitamin B2 to improve mobility, 30 mg every 8 h, 44-71 % (Coimbra 2003);

 - intense physical exercise, 35 % improvement (Alberts 2009);

 - N-acetylcysteine or NAC, a precursor of glutathione, improves motor and non-motor skills (Monti 2019)

 - vitamin C to reduce oxidation and oxidative damage from levodopa residues (Riederer 1989, Pardo 1993, Berg 2001...);

 - milk thistle in capsules to protect the overloaded liver (300 mg per day, books by neurologists Lombard and Marjama-Lyons);

 - the folic acid to reduce the dangerous homocysteine (Ahlskog, Gonzalez Maldonado, etc.), alone or with B12 and B6

 - a low level of vitamin B12 worsens and the necessary improvement in motor and cognitive function (Christine 2018, McCarter 2019);

 - the omega-3 pearls EPA and DHA for depression and for many other things -thus avoiding excess protein, but essential in 50-80 grams to synthesize neurotransmitters- (Silva 2008);

 - Vitamin B6 from food, brewer's yeast or mild supplements, no more than 25 mg as mentioned in the levodopa leaflets - because without B6 there's no dopamine - and several neurologists in their books and studies, such as Ahlskog, Marjama Lyons, Siniscalchi.

 - vitamin B3 in appropriate doses and supervised by the specialist, to treat the mind and psychosis resulting from long-term medication (books and articles by the famous neuropsychiatrist Abram Hoffer);

 - numerous studies have found high percentages of neuropathy in Parkinson's patients compared to (healthy) controls Vitamin B12 deficiency is the most common cause (Zis 2017).

 - ketogenic diet (Vanitallie 2005). 43 % improvement in motor symptoms;

 - thiamin B1 (Luong 2012);

 - NADH (Black 1986);

 . vitamin B6 (Tan 2005);

 - GDNF (Gill 2005) - vitamin D regulates the gene that produces it;

 - glutathione (Sechi 1996).

4) According to the studies published so far, THE SEVERITY OF THE VERY DISEASE OR ITS SYMPTOMS depends on:

 - level of magnesium (Barbiroli 1999);

 - glutathione level (Perry 1982, Riederer 1989, Sechi 1996, Jenner 1998);

 - level of the toxic homocysteine (Yasui 2000, Muller 2001, Christine 2018, Saadat 2018);

 - level of B12 (Leigh 2018, Christine 2018, McCarter 2019).

 - vitamin D (Suzuki 2012, Liu 2014).

"To see what is in front of one's nose needs a constant struggle." George Orwell